COLCRYS (Colchicine)
$80.00
Colchicine is a medication used for gout. It works in many different ways, including activating anti-inflammatory processes and interfering with cells involved in inflammation. Researchers think that colchicine could work similarly to tocilizumab (Actemra) in COVID-19 patients in that it might be helpful if the immune system becomes too activated and a cytokine storm occurs. A large clinical trial is currently seeing if colchicine, when given soon after a COVID-19 diagnosis, can lower the chances of hospitalization and death.
Quantity
Clinical Trial
There has also been some media coverage of the COLCORONA study, which is not yet peer-reviewed. Researchers found that the rate of death and hospitalization was lower in non-hospitalized, high-risk COVID-19 patients who got colchicine compared to those who did not (4.7% vs. 5.8%, respectively). The need for mechanical ventilation was also lower in the colchicine group (0.5% vs. 1.0%). However, these findings were not statistically significant, meaning they could have happened due to random chance.
Uses
Colchicine is a medicine that is used to prevent or treat attacks of gout, a condition caused by too much uric acid in the blood. Uric acid can form crystals that cause inflammation and pain in the joints.
How Colchicine Works
Mechanism of Action
Colchicine hinders the formation of microtubules, which are crucial components of cells, thus preventing cell division and interfering with various cellular processes.
Inhibition of Microtubule Formation
Colchicine hinders the growth of microtubules, which plays a role in reducing the cell's ability to move and thereby dampening inflammation.
Anti-Inflammatory Effects
The medication reduces the number of neutrophils that enter the inflamed areas, which helps relieve the symptoms.
Side Effects of Colchicine
Common Side Effects
Feeling sick. Throwing up Tiredness or general discomfort Skin-related symptoms like rashes
Severe Side Effects
Myelosuppression refers to a condition where the bone marrow functioning is impaired. Neuromuscular toxicity can lead to muscle pain or weakness. In some cases, organ failure may occur, specifically renal or hepatic failure.
Warnings
Liver and Kidney Impairment
People who have liver or kidney problems should be careful when using Colchicine. There is a chance of the medication building up in their system, which can lead to adverse side effects.
Cardiovascular Risks
Colchicine has been linked to complications affecting the heart and blood vessels. While not common, there have been cases of heart rhythms and fluctuations in blood pressure, so it's essential to closely monitor these factors.